Discourses of language acquisition and identity in the life histories of four white South African men, fluent in isiXhosa

A post-structuralist framework (Foucault, 1976; Weedon, 1997) is used to explore language acquisition and identity construction in the life histories of four multilingual white South African men, who became fluent in the African language of isiXhosa in the racially-divided world of Apartheid South Africa, at a time when law and policy made fluency in an African language unusual for whites. Theories used within the 'social turn' in Second Language Acquisition (Block, 2003; Norton, 2000), as well as the social learning theory of Lave and Wenger (1991), support an exploration of how the men acquired this language on the farms in the Eastern Cape where they spent their early years. The identity implications of the men's multilingualism are examined using post-colonial studies of race, 'whiteness' and hybridity (Bhabha, 1994; Frankenberg, 1993; Hall, 1992a). The study was undertaken using Life History methodology (Hatch & Wisniewsky, 1995) and biographic interviewing methods developed within the Social Sciences (Wengraf, 2001). Poststructuralist discourse analysis (Wetherell & Potter, 1992), together with aspects of narrative analysis (Brockmeier, 2000), were used to analyse the data. The study contributes to research into naturalistic language acquisition, using theories from the 'social turn', and analysing a bilingual context in which language, power, race and identity interact in unique ways. The findings endorse the importance of a post-structuralist framing for the Communities of Practice model (Wenger, 1998), and show that participation in target-language communities requires investment by learners in identities which ameliorate the inequities of power relations. The study shows that isiXhosa can become linguistic capital (Bourdieu, 1991) for white South Africans, depending on context and the isiXhosa register they use. It demonstrates that Apartheid discourse ascribes to the men an identity which is indisputably white, but that early experiences shared with isiXhosa-speakers shape their lives and form a potentially antihegemonic facet of their identities

Inherent biophysical stability of foot-and-mouth disease SAT1, SAT2 and SAT3 viruses

Foot-and-mouth disease (FMD) virus (FMDV) isolates show variation in their ability to withstand an increase in temperature. The FMDV is surprisingly thermolabile, even though this virus is probably subjected to a strong extracellular selective pressure by heat in hot climate regions where FMD is prevalent. The three SAT serotypes, with their particularly low biophysical stability also only yield vaccines of low protective capacity, even with multiple booster vaccinations. The aim of the study was to determine the inherent biophysical stability of field SAT isolates. To characterise the biophysical stability of 20 SAT viruses from Southern Africa, the thermofluor assay was used to monitor capsid dissociation by the release of the RNA genome under a range of temperature, pH and ionic conditions. The SAT2 and SAT3 viruses had a similar range of thermostability of 48–54 °C. However, the SAT1 viruses had a wider range of thermostability with an 8 °C difference but with many viruses being unstable at 43–46 °C. The thermostable A-serotype A24 control virus had the highest thermostability of 55 °C with some SAT2 and SAT3 viruses of similar thermostability. There was a 10 °C difference between the most unstable SAT virus (SAT1/TAN/2/99) and the highly stable A24 control virus. SAT1 viruses were generally more stable compared to SAT2 and SAT3 viruses at the pH range of 6.7–9.1. The effect of ionic buffers on capsid stability showed that SAT1 and SAT2 viruses had an increased stability of 2–9 °C and 2–6 °C, respectively, with the addition of 1 M NaCl. This is in contrast to the SAT3 viruses, which did not show improved stabilisation after addition of 1 M or 0.5 M NaCl buffers. Some buffers showed differing results dependent on the virus tested, highlighting the need to test SAT viruses with different solutions to establish the most stabilising option for storage of each virus. This study confirms for the first time that more stable SAT field viruses are present in the southern Africa region. This could facilitate the selection of the most stable circulating field strains, for adaptation to cultured BHK-21 cells or manipulation by reverse genetics and targeted mutation to produce improved vaccine master seed viruses.The Vaccine Initiative (ESCP) in South Africa.http://www.elsevier.com/locate/virusres2020-04-15hj2019BiochemistryGeneticsMicrobiology and Plant PathologyVeterinary Tropical Disease

Letter to the Editor:A possible threat to data integrity for online qualitative autism research

Researchers are increasingly relying on online methods for data collection, including for qualitative research involving interviews and focus groups. In this letter, we alert autism researchers to a possible threat to data integrity in such studies: “scammer” participants, who may be posing as autistic people and/or parents of autistic children in research studies, presumably for financial gain. Here, we caution qualitative autism researchers to be vigilant of potential scammer participants in their online studies and invite a broader discussion about the implications of such fraudulent acts

Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Unlike familial Alzheimer's disease, we have been unable to accurately predict symptom onset in presymptomatic familial frontotemporal dementia (f-FTD) mutation carriers, which is a major hurdle to designing disease prevention trials. We developed multimodal models for f-FTD disease progression and estimated clinical trial sample sizes in C9orf72, GRN and MAPT mutation carriers. Models included longitudinal clinical and neuropsychological scores, regional brain volumes and plasma neurofilament light chain (NfL) in 796 carriers and 412 noncarrier controls. We found that the temporal ordering of clinical and biomarker progression differed by genotype. In prevention-trial simulations using model-based patient selection, atrophy and NfL were the best endpoints, whereas clinical measures were potential endpoints in early symptomatic trials. f-FTD prevention trials are feasible but will likely require global recruitment efforts. These disease progression models will facilitate the planning of f-FTD clinical trials, including the selection of optimal endpoints and enrollment criteria to maximize power to detect treatment effects

Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Unlike familial Alzheimer's disease, we have been unable to accurately predict symptom onset in presymptomatic familial frontotemporal dementia (f-FTD) mutation carriers, which is a major hurdle to designing disease prevention trials. We developed multimodal models for f-FTD disease progression and estimated clinical trial sample sizes in C9orf72, GRN and MAPT mutation carriers. Models included longitudinal clinical and neuropsychological scores, regional brain volumes and plasma neurofilament light chain (NfL) in 796 carriers and 412 noncarrier controls. We found that the temporal ordering of clinical and biomarker progression differed by genotype. In prevention-trial simulations using model-based patient selection, atrophy and NfL were the best endpoints, whereas clinical measures were potential endpoints in early symptomatic trials. f-FTD prevention trials are feasible but will likely require global recruitment efforts. These disease progression models will facilitate the planning of f-FTD clinical trials, including the selection of optimal endpoints and enrollment criteria to maximize power to detect treatment effects

Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry

IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes